INTEGRATIVE ANALYSIS OF BULK AND SINGLE-CELL RNA-SEQ REVEALS THE MOLECULAR CHARACTERIZATION OF THE IMMUNE MICROENVIRONMENT AND OXIDATIVE STRESS SIGNATURE IN MELANOMA

Background: The immune microenvironment and oxidative stress of melanoma show significant heterogeneity, which affects tumor growth, invasion and treatment response.Single-cell and bulk RNA-seq data were used to explore the heterogeneity of the immune microenvironment and oxidative stress of melanoma.Methods: The R package Seurat facilitated the an

Elham Rouhollahi,1 Soheil Zorofchian Moghadamtousi,2 Nawal Al-Henhena,3 Thubasni Kunasegaran,1 Mohadeseh Hasanpourghadi,4 Chung Yeng Looi,4 Sri Nurestri Abd Malek,2 Khalijah Awang,5 Mahmood Ameen Abdulla,3 Zahurin Mohamed1 1Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, 2Institute of Biological Sciences, Faculty of Sc

The paper considers the class of Hamiltonian systems with two degrees of freedom.Based on the classical normal form, according to the rules of Born-Jordan and Weyl-MacCoy, its quantum analogs are constructed for which the eigenvalue problem is solved and approximate formulas for the energy spectrum are found.For particular values of the parameters

Model-Based Definition (MBD) is an emerging methodology that plays a central role in transforming traditional manual industry practices to automation through machine-to-machine communication.MBD captures and re-uses the data used by these new practices in a digital format that seamlessly transfers information to enterprise stakeholders involved in

Purpose/objectivesRecently a 1.5 Tesla MR Linac has been FDA approved and is commercially available.Clinical Gift Set series describing treatment methods and outcomes for upper abdominal tumors using a 1.5 Tesla MR Linac are lacking.We present the first clinical series of upper abdominal tumors treated using a 1.5 Tesla MR Linac along with the acqu